Tasneem Motiwala Selected Research

Class 3 Receptor-Like Protein Tyrosine Phosphatases

8/2013	Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.
12/2011	AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia.
7/2010	Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib.
2/2009	Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity.
6/2007	Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia.
9/2004	Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer.
9/2003	Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas.

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Tasneem Motiwala Research Topics

Disease

17	Neoplasms (Cancer) 09/2020 - 09/2003
8	Hepatocellular Carcinoma (Hepatoma) 09/2020 - 09/2003
5	Lung Neoplasms (Lung Cancer) 01/2018 - 09/2004
4	Leukemia 08/2013 - 02/2009
3	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/2011 - 06/2007
2	Liver Neoplasms (Liver Cancer) 01/2018 - 10/2006
2	Carcinogenesis 02/2009 - 06/2007
1	Neoplasm Metastasis (Metastasis) 01/2018
1	Disease Progression 10/2017
1	Lymphoma (Lymphomas) 04/2015
1	Carcinoma (Carcinomatosis) 01/2014
1	Colonic Neoplasms (Colon Cancer) 04/2010
1	Breast Neoplasms (Breast Cancer) 02/2009
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2009
1	Inflammation (Inflammations) 03/2007

Drug/Important Bio-Agent (IBA)

7	Class 3 Receptor-Like Protein Tyrosine PhosphatasesIBA 08/2013 - 09/2003
4	Protein Tyrosine PhosphatasesIBA 12/2011 - 08/2005
3	Sorafenib (BAY 43-9006)FDA Link 09/2020 - 10/2017
3	EnzymesIBA 01/2018 - 09/2003
3	hydrogen sulfite (bisulfite)IBA 08/2013 - 09/2003
3	Phosphotransferases (Kinase)IBA 07/2010 - 11/2008
3	MethyltransferasesIBA 04/2010 - 09/2003
3	DNA (Deoxyribonucleic Acid)IBA 04/2010 - 09/2003
2	Pharmaceutical PreparationsIBA 09/2020 - 10/2017
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2018 - 11/2008
2	Histones (Histone)IBA 04/2015 - 04/2010
2	Biomarkers (Surrogate Marker)IBA 04/2010 - 10/2006
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2009 - 08/2005
2	Tyrosine (L-Tyrosine)FDA Link 01/2009 - 08/2005
2	CCAAT-Enhancer-Binding Protein-alphaIBA 11/2008 - 03/2007
2	Choline (Choline Chloride)IBA 10/2006 - 09/2003
2	Folic Acid (Vitamin M)FDA LinkGeneric 10/2006 - 09/2003
2	Methionine (L-Methionine)FDA Link 10/2006 - 09/2003
1	Adenosine Triphosphate (ATP)IBA 05/2018
1	sapanisertibIBA 05/2018
1	NucleotidesIBA 01/2018
1	RNA (Ribonucleic Acid)IBA 01/2018
1	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 01/2018
1	zerumboneIBA 01/2018
1	Glucose-6-PhosphateIBA 01/2018
1	LipidsIBA 01/2018
1	Biological ProductsIBA 01/2018
1	Arginine (L-Arginine)FDA Link 04/2015
1	MicroRNAs (MicroRNA)IBA 01/2014
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 12/2011
1	Proteins (Proteins, Gene)FDA Link 12/2011
1	pazopanib FDA Link 07/2010
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 07/2010
1	Transcription Factors (Transcription Factor)IBA 04/2010
1	Estrogens (Estrogen)FDA Link 02/2009
1	Tamoxifen FDA LinkGeneric 02/2009
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 11/2008
1	Histone Deacetylase InhibitorsIBA 11/2008
1	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2007
1	MetallothioneinIBA 03/2007
1	Diethylnitrosamine (N-Nitrosodiethylamine)IBA 03/2007
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 03/2007
1	Histone Deacetylases (Histone Deacetylase)IBA 08/2005
1	Ribosomal RNAIBA 02/2004
1	Messenger RNA (mRNA)IBA 09/2003
1	Azacitidine (5 Azacytidine)FDA Link 09/2003

Therapy/Procedure

5	Therapeutics 09/2020 - 06/2005